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To date, individual GWASstudies on alcohol dependence and related phenotypes have been relatively modestin size, and most do not reach genome-wide significance. This may reflect boththe limited sample sizes and the clinical and genetic heterogeneity of thedisease. As noted above, the functional ADH1B polymorphism isnot represented on GWAS platforms; GABA-receptor genes are often nominallysignificant but…
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